The optional dispersion unit M-Jet ensures effective sample preparation of powdery materials. Hence, the Camsizer m1 is the ideal solution when it comes to characterizing powders and suspensions like pharmaceutical ingredients and excipients or fine abrasives and polishing agents. This measurement method is perfectly suited for high-resolution analysis of narrow particle size distributions in the lower micron range while simultaneously determining the particle shape. The Camsizer m1 operates on the basis of static image analysis (ISO 13322-1) and covers a measuring range from 0.5 µm to 1500 µm. Membrane Osmometry is another suitable technique but it is not possible to use this technology as online detector and the resolution and molar mass range is much more restricted than what can be expected from light scattering.Fully Automated Static Image Analysis with the Camsizer m1 Particle size & particle shape analysis of fine powders RETSCH Technology introduces the new Camsizer m1 as the latest addition to their powerful range of optical particle analyzers. Mass Spectroscopy has become very famous in the last decade, but this technique also requires a big investment and does not reach the same upper molar mass range as light scattering does. Analytical Ultracentrifugation for example shows high resolution but is much more expensive and complicated and has longer run times. Other techniques, which are rather more complementary than competing, are Analytical Ultracentrifugation (AUC), Mass Spectroscopy (MS) and Membrane Osmometry (MO). The scientific attractiveness of light scattering is based on the unique combination of high sensitivity, high resolution, easy handling and fast analysis times. An additional advantage is that sample fractions can be recovered for further subsequent analysis with other techniques after leaving the detector. Thus the combination of a separation technique and a light scattering detection technique provides a very powerful characterization tool which exceeds the performance of the single separation or the single detection technology when used alone. After the separation the eluting monodisperse sample fractions can be ideally sized online by light scattering. Field-Flow Fractionation and Size Exclusion Chromatography provide high resolution fractions of the polymers/particles under investigation. A solution to overcome this limitation is the combination of a separation technique, such as Field-Flow Fractionation (FFF) or Size Exclusion Chromatography (SEC), coupled with online light scattering detection (Flow Mode). Batch Mode analysis is easy to perform but in case of crude complex sample mixtures with a broad and or multi-modal distribution this approach has significant limitations as it is difficult to calculate the correct molar mass and particle size distribution with light scattering only. Light scattering can be done in Batch Mode and or in Flow Mode. A correlation function is established using this light scattering data and from that the Hydrodynamic Radius can be calculated from the Dynamic Light Scattering data. The fluctuation of the scattered light at a certain angle as the effect of the Brownian Motion of the molecules and particles is detected in Dynamic Light Scattering.
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